Redefining In-Breast Tumor Recurrence: Unveiling Metastatic Dynamics and Shifting the Focus to Overall Survival in Breast Cancer Surgery Assessment
Kefah Mokbel, Munaser Alamoodi · 2023
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Description
Kefah Mokbel and Munaser Alamoodi argue for rethinking what counts as failure after breast-saving surgery in a commentary from 2023. A study of nearly fifty-six hundred patients found higher in-breast recurrence when first cuts left positive margins. That held even after repeat cuts cleared the margins. Young patients and delayed treatment showed the effect most.
The commentators reason the data acquit surgical technique. Repeat excision had removed the leftover disease, yet recurrence still rose. Biology, they say, drives the pattern: aggressive tumors recur wherever they start. Judging surgery by local recurrence alone may mislead. Overall survival deserves the central place in assessment. The piece pushes trial designers to move the goalposts accordingly.
Catalog record
| CREATOR | Kefah Mokbel, Munaser Alamoodi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |