Unraveling the Concealed Transcriptomic Landscape of PTEN in Human Malignancies
Michaela A Boti, Panagiotis G Adamopoulos, Dido Vassilacopoulou, Andreas Scorilas · 2023
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Description
Michaela Boti and co-authors map hidden RNA transcripts of the PTEN gene in cancers in this 2023 paper. PTEN is a brake on a major growth pathway in cells. Losing that brake helps many cancers grow. The gene protein role is well studied, but its full set of RNA messages was poorly known.
Standard direct RNA sequencing misses rare messages because it reads too shallowly. The team built a targeted method that enriches PTEN messages first. It combines short and long read sequencing for accuracy and completeness. Many previously unknown transcripts appeared across cancer and normal cell lines. Their expression patterns varied widely by cell type. The catalog opens new angles on how this key gene is controlled.
Catalog record
| CREATOR | Michaela A Boti, Panagiotis G Adamopoulos, Dido Vassilacopoulou, Andreas Scorilas |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |