Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer
Haotian Chen, Yao Zhang, Xingyu Chen, Runshi Xu, Yuxing Zhu, Dong He, YaXin Cheng, Zhanwang Wang, Xiang Qing, Ke Cao · 2023
Read Hypoxia is correlated with the tumor immune microenvironment: Potential application of immunotherapy in bladder cancer by Haotian Chen, Yao Zhang, Xingyu Chen, Runshi Xu, Yuxing Zhu, Dong He, YaXin Cheng, Zhanwang Wang, Xiang Qing, Ke Cao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10757107.txt.
Description
Haotian Chen and co-authors connect low oxygen inside bladder tumors to immune behavior in a 2023 study. Oxygen-starved tumors often resist immune therapy. The team mined data on 408 bladder cancer samples to find hypoxia-linked signs that could guide treatment choices.
The samples split into two subtypes, one packed with immune cells and immune marker activity. A hypoxia score built from gene readings separated patients further: high-score tumors drew more immune infiltration and were predicted to answer immune therapy better. Tissue staining spotlighted one gene, TLR8, as tied to the immune pattern. The authors offer the subtype and score as planning tools for clinicians.
Catalog record
| CREATOR | Haotian Chen, Yao Zhang, Xingyu Chen, Runshi Xu, Yuxing Zhu, Dong He, YaXin Cheng, Zhanwang Wang, Xiang Qing, Ke Cao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |