Cathepsin V drives lung cancer progression by shaping the immunosuppressive environment and adhesion molecules cleavage
Lifei Zhu, Qi Zeng, Jinxiang Wang, Fan Deng, Shi Jin · 2023
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Description
Lifei Zhu and four co-authors show that the protease cathepsin V drives lung cancer spread, in work from 2023. The enzyme chews up matrix proteins and is tied to poor outlook in several cancers. In lung tumors it was raised, and patients with more of it fared worse. Lab and animal tests cast it as an active driver of metastasis rather than a bystander.
The enzyme works by cutting adhesion molecules such as fibronectin and the cadherins, loosening cells from their moorings. A designed antibody that blocks the cutting slowed migration and invasion, and in mice it curbed spread. High enzyme levels also matched cold immune surroundings, which widens the case for targeting it.
Catalog record
| CREATOR | Lifei Zhu, Qi Zeng, Jinxiang Wang, Fan Deng, Shi Jin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |