Down-regulation of EZH2 genes targeting RUNX3 affects proliferation, invasion, and metastasis of human colon cancer cells by Wnt/β-catenin signaling pathway
Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang Lu · 2023
Read Down-regulation of EZH2 genes targeting RUNX3 affects proliferation, invasion, and metastasis of human colon cancer cells by Wnt/β-catenin signaling pathway by Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang Lu (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10756104.txt.
Description
Guanli Liang and co-authors study a gene silencer that may slow colon cancer when dialed down in a 2023 lab paper. The gene, EZH2, helps switch other genes off and is often overactive in tumors. A partner gene, RUNX3, acts as a brake that EZH2 can suppress.
In two colon cancer cell lines, muting EZH2 lifted the brake gene and cut several cancer-linked markers. Cells grew, invaded, and spread less, while more of them died on cue. Key growth pathway proteins also fell. Grafts in mice echoed the dish results. The pathway named in the title carries the effect, the authors conclude.
Catalog record
| CREATOR | Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang Lu |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |