Maternal Serum Folic Acid Levels and Onset of Kawasaki Disease in Offspring During Infancy
Sayaka Fukuda, Shiro Tanaka, Chihiro Kawakami, Tohru Kobayashi, Shuichi Ito · 2023
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Description
Sayaka Fukuda and four co-authors, with the Japan Environment and Children's Study Group, ask whether a mother's folic acid level affects her baby's risk of Kawasaki disease, in a 2023 study. The disease inflames blood vessels in infants and small children, and no firm risk factors were known. A previous report had hinted at a folate link.
The nationwide birth cohort followed 87,702 children for their first year; 336 developed the disease. Mothers who took supplements had higher blood folate, as expected. Babies of mothers with higher late-pregnancy folate levels developed Kawasaki disease less often: 0.27 percent versus 0.41 percent, about a third lower odds after adjustment. Supplement timing analyses accompanied the blood-level result. The authors present folate status as the first reproducible lead on preventing this puzzling illness, while stopping short of prescribing supplements for that purpose.
Catalog record
| CREATOR | Sayaka Fukuda, Shiro Tanaka, Chihiro Kawakami, Tohru Kobayashi, Shuichi Ito |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |