Transmembrane protein 120A (TMEM-120A/TACAN) coordinates with PIEZO channel during Caenorhabditis elegans reproductive regulation
Xiaofei Bai, Andy Golden · 2024
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Description
Xiaofei Bai and Andy Golden study how a touch-sensing pair of proteins runs reproduction in a tiny worm. One protein was thought to both sense force and trim fats, and it reins in a known force channel. Their study, published in 2023, deletes the worm's version of the first protein and watches the breeding tract.
Worms without the protein showed warped germ lines, lost fertility, and small broods. Live views caught eggs pinched as they passed a squeezing gate. Cutting the protein only in the body, or only in the germ line, each shrank broods, so both sources count. Losing it also eased the harm from losing the force channel. The pair seems to work as one team, the authors say.
Catalog record
| CREATOR | Xiaofei Bai, Andy Golden |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |