Developing Single-Atomic Manganese Nanozymes for Synergistic Mild Photothermal/Multienzymatic Therapy
Cun-shuo Wang, Hai-bin Xue, Liang Zhuang, Hai-peng Sun, Hua Zheng, Shuai Wang, Shan He, Xiao-bo Luo · 2023
Read Developing Single-Atomic Manganese Nanozymes for Synergistic Mild Photothermal/Multienzymatic Therapy by Cun-shuo Wang, Hai-bin Xue, Liang Zhuang, Hai-peng Sun, Hua Zheng, Shuai Wang, Shan He, Xiao-bo Luo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10753745.txt.
Description
Cun-shuo Wang and co-authors report a nanomedicine study, published in 2023, on treating bone cancer with single atoms of manganese. Osteosarcoma tumors resist treatment partly because they lack oxygen and guard themselves with antioxidants. The team spread individual manganese atoms across black nitrogen doped carbon sheets, making a material that both heats under near infrared light and acts like several enzymes at once.
The enzyme like actions turn tumor hydrogen peroxide into oxygen, then into a toxic radical, while draining the tumor's antioxidant shield and disabling one of its guard proteins. Heat and chemical attack together build up fat damage inside tumor cells. The authors present the combined mild heating and multi enzyme strategy as a new route against this stubborn cancer.
Catalog record
| CREATOR | Cun-shuo Wang, Hai-bin Xue, Liang Zhuang, Hai-peng Sun, Hua Zheng, Shuai Wang, Shan He, Xiao-bo Luo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |