Control points for design of taxonomic composition in synthetic human gut communities
Bryce M Connors, Jaron Thompson, Sarah Ertmer, Ryan L Clark, Brian F Pfleger, Ophelia S Venturelli · 2023
Read Control points for design of taxonomic composition in synthetic human gut communities by Bryce M Connors, Jaron Thompson, Sarah Ertmer, Ryan L Clark, Brian F Pfleger, Ophelia S Venturelli (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10752370.txt.
Description
Bryce Connors and colleagues learn to steer a synthetic gut community like a garden, in this study from twenty twenty-three. Fake microbiomes promise much for medicine and industry, but their membership usually drifts where it will. The team worked with a ten-species stand-in for the human gut community.
Their recipe has two stages. First, they tuned the growth medium and the starting dose of each species, and found that what governs a species alone in a dish also steers it inside the crowd. Second, varied starting mixes let a computer model infer how each pair of species helps or hinders the other, and those inferences matched separate tests. With the model in hand, they designed small communities that held steady over time, and others that kept changing. The work turns community building from guesswork toward design.
Catalog record
| CREATOR | Bryce M Connors, Jaron Thompson, Sarah Ertmer, Ryan L Clark, Brian F Pfleger, Ophelia S Venturelli |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |