Precisional detection of lymph node metastasis using tFCM in colorectal cancer
Dan Yang, Jingling Tang, Yunhuan Zhen, Jindong Yuan, Pingsheng Hu, Xiaoyun Li, Hang Du, Xiaolan Zhang, Yuan Yang · 2023
Read Precisional detection of lymph node metastasis using tFCM in colorectal cancer by Dan Yang, Jingling Tang, Yunhuan Zhen, Jindong Yuan, Pingsheng Hu, Xiaoyun Li, Hang Du, Xiaolan Zhang, Yuan Yang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10751999.txt.
Description
Dan Yang and eight co-authors published a diagnostics study in twenty twenty-three on spotting lymph node spread in colorectal cancer with triple-parameter flow cytometry. Finding cancer in lymph nodes guides treatment, but checking tissue slices is slow and can miss small deposits. The team built a faster test using three cell markers.
First they confirmed the markers appear on colorectal cancer cells but not on normal blood cells, using spiked samples with a near-perfect linear response. Then they tested thirty-six lymph nodes from patients against standard pathology. The flow method caught micro-metastases and isolated tumor clusters that slices alone risked missing. The authors argue it cuts misdiagnosis and speeds staging.
Catalog record
| CREATOR | Dan Yang, Jingling Tang, Yunhuan Zhen, Jindong Yuan, Pingsheng Hu, Xiaoyun Li, Hang Du, Xiaolan Zhang, Yuan Yang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |