PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84
Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L Carlson, Samantha T Reyes, Isaac M Jackson, Lorenzo Suigo, Audrey Luo, Sydney C Nagy, Ermanno Valoti, Graeme Milligan, Frezghi · 2023
Read PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84 by Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L Carlson, Samantha T Reyes, Isaac M Jackson, Lorenzo Suigo, Audrey Luo, Sydney C Nagy, Ermanno Valoti, Graeme Milligan, Frezghi (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10751761.txt.
Description
A large research team built and tested two imaging tracers for a receptor tied to immune flare-ups in the brain, in work published in 2023. The receptor, GPR84, rises on immune cells when long-term inflammation switches on. A tracer that sticks to it could let scans show that inflammation as it happens.
The team made two carbon-11 tracers and checked them in lab cells first. Both stuck far more to cells carrying the receptor than to plain cells, and a blocking drug cut that binding by over 90 percent. In healthy mice, one tracer entered the brain better and cleared in a cleaner pattern. In mice with body-wide and brain inflammation, that tracer lit up the brain, liver, lung, and spleen, and the blocker confirmed the signal was on target.
Catalog record
| CREATOR | Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L Carlson, Samantha T Reyes, Isaac M Jackson, Lorenzo Suigo, Audrey Luo, Sydney C Nagy, Ermanno Valoti, Graeme Milligan, Frezghi |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |