Construction of a ferroptosis-based prognostic model for breast cancer helps to discriminate high/low risk groups and treatment priority
Liyong Zhang, Tingting Zhao, Xiujuan Wu, Hao Tian, Pingping Gao, Qingqiu Chen, Ceshi Chen, Yi Zhang, Shushu Wang, Xiaowei Qi, Na Sun · 2023
Read Construction of a ferroptosis-based prognostic model for breast cancer helps to discriminate high/low risk groups and treatment priority by Liyong Zhang, Tingting Zhao, Xiujuan Wu, Hao Tian, Pingping Gao, Qingqiu Chen, Ceshi Chen, Yi Zhang, Shushu Wang, Xiaowei Qi, Na Sun (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10751362.txt.
Description
Liyong Zhang and ten co-authors build a risk score for breast cancer from genes of an iron-driven cell death, in a 2023 study. That death style, ferroptosis, may shape how tumors grow and answer drugs, but its gene cast in breast cancer was unmapped. The team sifted public tumor data and immune and drug files, landing on 73 candidate genes. Tests for survival links cut the list down.
A shrinkage method then picked ten genes for the final score. The score split patients into high and low risk with real gaps in outcome. Immune cell mixes differed between the risk groups, which may guide drug choice. Lab checks in cancer cell lines and stained tumor samples confirmed the genes are truly active in the disease. The authors offer the score as a planning aid, not a verdict.
Catalog record
| CREATOR | Liyong Zhang, Tingting Zhao, Xiujuan Wu, Hao Tian, Pingping Gao, Qingqiu Chen, Ceshi Chen, Yi Zhang, Shushu Wang, Xiaowei Qi, Na Sun |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |