TICRR serves as a prognostic biomarker in lung adenocarcinoma with implications in RNA epigenetic modification, DDR pathway, and RNA metabolism
Xunbo Zheng, Li Han, Jun Guan, Chenteng Chen, Yue Zhang, Jiali Zhang, Yiran Zhang, Siyao Liu, Junyan Su, Mengyuan Liu, Hanxing Huang · 2023
Read TICRR serves as a prognostic biomarker in lung adenocarcinoma with implications in RNA epigenetic modification, DDR pathway, and RNA metabolism by Xunbo Zheng, Li Han, Jun Guan, Chenteng Chen, Yue Zhang, Jiali Zhang, Yiran Zhang, Siyao Liu, Junyan Su, Mengyuan Liu, Hanxing Huang (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10751343.txt.
Description
Xunbo Zheng and co-authors study a gene called TICRR in lung adenocarcinoma, a common form of lung cancer. The gene helps start DNA copying in cells and has been linked to tumor growth. The team measured the gene in tumor and nearby normal tissue. They also mined large cancer data sets to link its levels to stage, survival, and cell traits.
The gene was far more active in tumors than in normal tissue, and high levels tracked with worse survival. Its levels rose with tumor stage and with heavy smoking and high counts of gene changes. Lab work that silenced the gene shifted cell growth and immune signals. A risk score built on the gene sorted patients well, so the authors propose it as a marker and drug target.
Catalog record
| CREATOR | Xunbo Zheng, Li Han, Jun Guan, Chenteng Chen, Yue Zhang, Jiali Zhang, Yiran Zhang, Siyao Liu, Junyan Su, Mengyuan Liu, Hanxing Huang |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |