Druggable genomic landscapes of high-grade gliomas
Paola Ghanem, Maria Fatteh, David Olayinka Kamson, Archana Balan, Michael Chang, Jessica Tao, Jaishri Blakeley, Christine Pratilas, Christine Pratilas, Taxiarchis Botsis, Rena Xian, Chris Gocke, Tseh Ming-Lin, Eitan Halper-Stromberg, Ying Zou, Kent Hardart, Jonathan Spiker, Kory Kreimeyer, Ting He, · 2023
Read Druggable genomic landscapes of high-grade gliomas by Paola Ghanem, Maria Fatteh, David Olayinka Kamson, Archana Balan, Michael Chang, Jessica Tao, Jaishri Blakeley, Christine Pratilas, Christine Pratilas, Taxiarchis Botsis, Rena Xian, Chris Gocke, Tseh Ming-Lin, Eitan Halper-Stromberg, Ying Zou, Kent Hardart, Jonathan Spiker, Kory Kreimeyer, Ting He, (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10749203.txt.
Description
Paola Ghanem and co-authors mapped in 2023 which gene changes in aggressive brain tumors can actually be hit by drugs. Survival gains from matched targeted drugs have been poor despite many promising targets. Using glioblastoma as the test case, the team studied hundreds of tumors and their mutation patterns.
Nearly a third of the changes sat in known hotspots, and the team matched changes to fifty-four targeted drugs. They then checked drug traits against real results and reviewed fifty patients whose cases went before a tumor board. The pattern explains why matches so often disappoint: the drug, the tumor spread, and timing all fight the plan.
Catalog record
| CREATOR | Paola Ghanem, Maria Fatteh, David Olayinka Kamson, Archana Balan, Michael Chang, Jessica Tao, Jaishri Blakeley, Christine Pratilas, Christine Pratilas, Taxiarchis Botsis, Rena Xian, Chris Gocke, Tseh Ming-Lin, Eitan Halper-Stromberg, Ying Zou, Kent Hardart, Jonathan Spiker, Kory Kreimeyer, Ting He, |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |