KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells
Ying Du, Hui Ye, Mei Lin, Lili Cao · 2023
Read KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells by Ying Du, Hui Ye, Mei Lin, Lili Cao (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748496.txt.
Description
A gene better known from metabolism may double as a brake on cervical cancer, and Ying Du, Hui Ye, Mei Lin, and Lili Cao tested its grip. Forcing extra KLF14 into two cervical cancer cell lines piled cells up in the S phase of their cycle, the copying stage. It also raised two cell-cycle proteins, along with activity in a stress signalling pathway.
Blocking that pathway loosened the pile-up; boosting it tightened the pile-up, in step with the proteins' levels. The brake depended on the gene's zinc-finger region, its DNA-gripping part. In mice, tumours carrying extra KLF14 grew slower, with the same pathway and proteins switched up inside them. The authors cast KLF14 as a tumour suppressor working through that pathway.
Catalog record
| CREATOR | Ying Du, Hui Ye, Mei Lin, Lili Cao |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |