Investigating the impact of human blood metabolites on the Sepsis development and progression: a study utilizing two-sample Mendelian randomization
Zhongqi Zhang, Yu Yin, Tingzhen Chen, Jinjin You, Wenhui Zhang, Yifan Zhao, Yankang Ren, Han Wang, Xiangding Chen, Xiangrong Zuo · 2023
Read Investigating the impact of human blood metabolites on the Sepsis development and progression: a study utilizing two-sample Mendelian randomization by Zhongqi Zhang, Yu Yin, Tingzhen Chen, Jinjin You, Wenhui Zhang, Yifan Zhao, Yankang Ren, Han Wang, Xiangding Chen, Xiangrong Zuo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748392.txt.
Description
Zhongqi Zhang and co-authors used genetic data in 2023 to test which blood chemicals truly help cause sepsis, the body's runaway response to infection that can kill within days. Many chemicals correlate with sepsis, but correlation cannot show which ones drive it.
Borrowing nature's own experiment, the team used gene variants that shift chemical levels as stand ins for lifelong exposure. Twenty-seven blood chemicals showed a causal link to sepsis catching or worsening. After strict statistical correction, one chemical stayed tied to death within twenty-eight days of sepsis. Pathway maps pointed to four chemical routes, with the handling of two plant like fats standing out. The work nominates targets for later drug studies.
Catalog record
| CREATOR | Zhongqi Zhang, Yu Yin, Tingzhen Chen, Jinjin You, Wenhui Zhang, Yifan Zhao, Yankang Ren, Han Wang, Xiangding Chen, Xiangrong Zuo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |