Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil
Ammara Akhtar, Muhammad Khurram Waqas, Arshad Mahmood, Saira Tanvir, Talib Hussain, Mohsin Kazi, Muhammad Ijaz, Mulazim Hussain Asim, Suhair Sunoqrot, Sara A Abdel Gaber · 2023
Read Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil by Ammara Akhtar, Muhammad Khurram Waqas, Arshad Mahmood, Saira Tanvir, Talib Hussain, Mohsin Kazi, Muhammad Ijaz, Mulazim Hussain Asim, Suhair Sunoqrot, Sara A Abdel Gaber (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748369.txt.
Description
Ammara Akhtar, Muhammad Waqas, Arshad Mahmood, and seven colleagues build, published in 2023, sticky nanoparticles to hold the hair drug minoxidil on the scalp longer. Minoxidil works where it lands, but washes and time clear it fast. The team wrapped the drug in ring-shaped sugar cages fitted with sulfur hooks. Those cages were packed with a gel-forming partner into nanoparticles. Lab checks sized the particles in the few-hundred nanometer range. Release of the drug ran slower from the hooked version.
On human hair, the hooked particles clung far longer than plain ones. Skin models took up and kept more drug. Rabbit skin showed no irritation from the new particles. The authors frame the stickiness as the whole point: longer contact means more drug where hair grows. They propose the system for scalp diseases beyond hair loss, wherever a topical drug must stay put to work.
Catalog record
| CREATOR | Ammara Akhtar, Muhammad Khurram Waqas, Arshad Mahmood, Saira Tanvir, Talib Hussain, Mohsin Kazi, Muhammad Ijaz, Mulazim Hussain Asim, Suhair Sunoqrot, Sara A Abdel Gaber |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |