Assessment of Immune Responses to a Trivalent Pichinde Virus-Vectored Vaccine Expressing Hemagglutinin Genes from Three Co-Circulating Influenza A Virus Subtypes in Pigs
Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Hinh Ly, Yuying Liang, Hiep L X Vu, Ralph A Tripp · 2023
Read Assessment of Immune Responses to a Trivalent Pichinde Virus-Vectored Vaccine Expressing Hemagglutinin Genes from Three Co-Circulating Influenza A Virus Subtypes in Pigs by Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Hinh Ly, Yuying Liang, Hiep L X Vu, Ralph A Tripp (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748346.txt.
Description
Sushmita Kumari and co-authors test a trivalent vaccine for swine influenza in pigs, built on a Pichinde virus vector. The vaccine carries the hemagglutinin genes of the three influenza A subtypes that circulate in pigs: H1N1, H1N2 and H3N2. An earlier single-strain version from the group had protected pigs against its matching strain.
Vaccinated pigs made neutralising and hemagglutination-blocking antibodies against all three strains. After challenge with the H1N1 strain, five of six vaccinated pigs showed no viral RNA in nose swabs or lung wash fluid. All unvaccinated pigs carried high viral loads in both sample types. The vector may suit multi-antigen swine vaccines, the authors conclude.
Catalog record
| CREATOR | Sushmita Kumari, Jayeshbhai Chaudhari, Qinfeng Huang, Phillip Gauger, Marcelo Nunes De Almeida, Hinh Ly, Yuying Liang, Hiep L X Vu, Ralph A Tripp |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |