Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes
Luana di Leandro, Martina Colasante, Giuseppina Pitari, Rodolfo Ippoliti · 2023
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Description
Luana di Leandro and co-authors review how to brew toxins for therapy in 2023. Lab made toxins can kill cancer cells or germs with precision. Making them is tricky because the toxin can poison its own host cell. Bacteria, yeast, and mammal cells each offer trade offs as factories.
The review sorts expression tactics that keep yields high and hosts alive. Uses span antimicrobials, cancer drugs, and vaccines. Three targeting styles are set out, from antibody guided toxins to suicide gene setups. Named examples range from plant and animal toxins to bacterial toxin parts.
Catalog record
| CREATOR | Luana di Leandro, Martina Colasante, Giuseppina Pitari, Rodolfo Ippoliti |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |