Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders
Laura Mihaela Isop, Andrea Elena Neculau, Radu Dan Necula, Cristian Kakucs, Marius Alexandru Moga, Lorena Dima, Agnieszka Sliwinska · 2023
Read Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders by Laura Mihaela Isop, Andrea Elena Neculau, Radu Dan Necula, Cristian Kakucs, Marius Alexandru Moga, Lorena Dima, Agnieszka Sliwinska (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748332.txt.
Description
Laura Mihaela Isop and co-authors review a common diabetes drug for possible use in brain-wasting diseases, in work from two thousand twenty-three. The drug is cheap and widely used, and animal work hints it may shield the brain. Demand for care in Alzheimer and Parkinson disease keeps rising.
The review traces how the drug works, from a key energy switch to gut and microbe effects. Targets inside cell power units and waste sacs are still being pinned down. Animal results look promising, but human trial results stay mixed and unclear. The authors call for trials designed around the drug's true targets.
Catalog record
| CREATOR | Laura Mihaela Isop, Andrea Elena Neculau, Radu Dan Necula, Cristian Kakucs, Marius Alexandru Moga, Lorena Dima, Agnieszka Sliwinska |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |