Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity
Jin Jin, Xujun Liang, Wu Bi, Ruijie Liu, Sai Zhang, Yi He, Qingming Xie, Shilei Liu, Ji-Chang Xiao, Pengfei Zhang, Fedora Grande, Abdallah Hamze · 2023
Read Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity by Jin Jin, Xujun Liang, Wu Bi, Ruijie Liu, Sai Zhang, Yi He, Qingming Xie, Shilei Liu, Ji-Chang Xiao, Pengfei Zhang, Fedora Grande, Abdallah Hamze (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748328.txt.
Description
Jin and co-authors identify a new compound that fights liver cancer by waking a metabolic enzyme, in a 2023 drug study. The starting point was fenofibrate, a lipid drug with weak anti-tumor effects. The team synthesized six derivatives and screened them on human liver cancer cells. One stood out, killing the cells at low doses and slowing their migration.
Tests showed the compound triggers apoptosis, programmed cell death, in the cancer cells. A thermal shift method in cells pointed to fumarate hydratase, a core metabolic enzyme, as its binding target, and follow-up assays confirmed activation. In mice carrying human tumors, the compound shrank growth through the same route. The authors present it as a candidate for further development against hepatocellular carcinoma.
Catalog record
| CREATOR | Jin Jin, Xujun Liang, Wu Bi, Ruijie Liu, Sai Zhang, Yi He, Qingming Xie, Shilei Liu, Ji-Chang Xiao, Pengfei Zhang, Fedora Grande, Abdallah Hamze |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |