From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kok · 2023
Read From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities by Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kok (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748240.txt.
Description
Predrag Sikiric and co-authors review fifty years of research tying dopamine to stomach ulcer healing in a 2023 paper. The story starts with a rat model: the chemical cysteamine reliably opens duodenal ulcers, mimicking human stress ulcers. Cysteamine blocks dopamine, which hinted the brain chemical protects the gut.
The review walks the timeline of evidence. Drugs that mimic dopamine healed ulcers across many studies, while blockers tended to provoke them, though odd exceptions appear under mild-stress conditions. Several gut peptides, including the lab's own BPC 157, slot into the same brain-gut story as dopamine's helpers. The authors try to reconcile the agonist-antagonist tangle and sketch what the pathway could offer therapy.
Catalog record
| CREATOR | Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kok |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |