Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges
Wanling Liu, Pascalle Mossel, Verena Schwach, Riemer H. J. A. Slart, Gert Luurtsema · 2023
Read Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges by Wanling Liu, Pascalle Mossel, Verena Schwach, Riemer H. J. A. Slart, Gert Luurtsema (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10748140.txt.
Description
Wanling Liu and colleagues review PET imaging of drug pump proteins in the heart, in work from 2023. ABC transporters spend cell energy to move molecules across membranes in many tissues. Heart drugs often stick to these pumps, which shapes drug levels and toxicity risk.
One pump, P-glycoprotein, guards how much drug reaches heart tissue in practice. PET scans can watch that pump work inside living organs with tagged tracers. Heart focused tracer studies remain few, so the review maps what exists today. Drug design and precise dosing both stand to gain from live pump reads. Gaps and hurdles for the young field close the survey.
Catalog record
| CREATOR | Wanling Liu, Pascalle Mossel, Verena Schwach, Riemer H. J. A. Slart, Gert Luurtsema |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |