Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine
David Balayssac, Julie Durif, Céline Lambert, Cristelle Dalbos, Eric Chapuy, Monique Etienne, Claire Demiot, Jérôme Busserolles, Vincent Martin, Vincent Sapin · 2023
Read Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine by David Balayssac, Julie Durif, Céline Lambert, Cristelle Dalbos, Eric Chapuy, Monique Etienne, Claire Demiot, Jérôme Busserolles, Vincent Martin, Vincent Sapin (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747971.txt.
Description
David Balayssac and co-authors ran a pilot study in rats in 2023 to find blood markers for nerve pain from cancer drugs. Four drugs that save lives can also harm nerves and cause lasting pain. No blood test yet works well to flag that harm early.
Rats got repeated doses of the four drugs, and the team tracked touch pain and thirty-one proteins in blood. Pain thresholds fell in all treated groups, but no marker shifted in a steady way across drugs. Three markers rose in at least two drug groups, and one drug group showed strong links to pain. The authors say more work must map timing and accuracy before any test is ready.
Catalog record
| CREATOR | David Balayssac, Julie Durif, Céline Lambert, Cristelle Dalbos, Eric Chapuy, Monique Etienne, Claire Demiot, Jérôme Busserolles, Vincent Martin, Vincent Sapin |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |