Investigation on Electrospun and Solvent-Casted PCL-PLGA Blends Scaffolds Embedded with Induced Pluripotent Stem Cells for Tissue Engineering
Mariella Rosalia, Martina Giacomini, Erika Maria Tottoli, Rossella Dorati, Giovanna Bruni, Ida Genta, Enrica Chiesa, Silvia Pisani, Maurilio Sampaolesi, Bice Conti · 2023
Read Investigation on Electrospun and Solvent-Casted PCL-PLGA Blends Scaffolds Embedded with Induced Pluripotent Stem Cells for Tissue Engineering by Mariella Rosalia, Martina Giacomini, Erika Maria Tottoli, Rossella Dorati, Giovanna Bruni, Ida Genta, Enrica Chiesa, Silvia Pisani, Maurilio Sampaolesi, Bice Conti (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747843.txt.
Description
Lab-grown body tissue needs a scaffold, a small frame that cells can live on and shape. Rosalia and nine co-authors build scaffolds from two body-safe plastics, PCL and PLGA, mixed in varying shares. They make the frames two ways: by spinning fine fibers, and by casting with salt-like grains that leave bubble-shaped pores. They then measure fiber size, stiffness, wetting, and water uptake.
Fiber spinning gave steady control: more PCL made thicker fibers and softer frames. Cast frames wet better and held stem cells alive well over five days. Spun frames soaked up ten times more water but their cast rivals were less even in quality, since the mix tended to separate. Both kinds let special stem cells keep their flexible, undifferentiated state. The authors weigh the trade-offs for growing tissue in the lab.
Catalog record
| CREATOR | Mariella Rosalia, Martina Giacomini, Erika Maria Tottoli, Rossella Dorati, Giovanna Bruni, Ida Genta, Enrica Chiesa, Silvia Pisani, Maurilio Sampaolesi, Bice Conti |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |