Impact of MgtC on the Fitness of Yersinia pseudotuberculosis
Peng Li, Hengtai Wang, Wei Sun, Jiabo Ding · 2023
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Description
Peng Li, Hengtai Wang, Wei Sun, and Jiabo Ding probe what a protein called MgtC does for a foodborne Yersinia bacterium, in a 2023 study. In cousins like Salmonella, MgtC helps bacteria survive inside immune cells when magnesium runs low. Whether it matters in Yersinia pseudotuberculosis, which mostly causes self-limiting diarrhea, was unclear.
Without MgtC, the bacterium grew poorly in low-magnesium broth and survived worse inside macrophages. Gene activity inside those cells shifted across 127 genes. In mice, the mutant was only mildly weaker, though the drop was real. The authors conclude MgtC supports fitness in harsh niches but is not the bacterium's main weapon.
Catalog record
| CREATOR | Peng Li, Hengtai Wang, Wei Sun, Jiabo Ding |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |