The CombE-IDMS Alternate Potency Method for H5N1 and H5N8 Cell-Based Vaccines
Matthew P Donohue, Zhijun Cao, Thomas Bowen, Robert Dickinson, Ying Zhang, Jiang Qian, Romain Paillot · 2023
Read The CombE-IDMS Alternate Potency Method for H5N1 and H5N8 Cell-Based Vaccines by Matthew P Donohue, Zhijun Cao, Thomas Bowen, Robert Dickinson, Ying Zhang, Jiang Qian, Romain Paillot (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747648.txt.
Description
Matthew Donohue and co-authors extend a mass-based potency test to bird flu vaccines. Their 2023 study deals with flu vaccine strength checks, which now rest on a diffusion test that needs matched sera and standards. In a fast pandemic, shipping those parts stalls release. Their method, CombE-IDMS, reads potency by mass tools with no antibodies or reference stock, and past work matched the standard test on seasonal vaccines.
Here the test faced pre-pandemic H5N1 and H5N8 materials, plain and boosted, after forced stress by heat, acid, oxidation, and freeze-thaw. Results tracked the standard test across all stress forms. The authors pitch it as a rapid backup for pandemic supply.
Catalog record
| CREATOR | Matthew P Donohue, Zhijun Cao, Thomas Bowen, Robert Dickinson, Ying Zhang, Jiang Qian, Romain Paillot |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |