Proteomic Analysis of the Mitochondrial Responses in P19 Embryonic Stem Cells Exposed to Florfenicol
Zhihua Dong, Xueke Hou, Xueying Wang, Zihui Shen, Huiqing Pang, Lingli Chen, Zhihong Yin, Fei Ren, Weiguo Li, Yaming Ge, Hongmei Ning, Dongfang Hu, Youssef Sari · 2023
Read Proteomic Analysis of the Mitochondrial Responses in P19 Embryonic Stem Cells Exposed to Florfenicol by Zhihua Dong, Xueke Hou, Xueying Wang, Zihui Shen, Huiqing Pang, Lingli Chen, Zhihong Yin, Fei Ren, Weiguo Li, Yaming Ge, Hongmei Ning, Dongfang Hu, Youssef Sari (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747307.txt.
Description
Zhihua Dong and eleven co-authors studied how a veterinary drug harms stem cells in a 2023 paper. The drug, florfenicol, is used against infections in animals, but it has toxic effects in many species. The team's earlier work showed it can damage heart development in chick embryos.
They exposed mouse stem cells that can turn into heart muscle cells. The drug cut the cells' growth and blocked their path into heart cells. A protein census found 148 proteins changed by the drug, many tied to the energy-making parts of the cell, the mitochondria. Follow-up tests confirmed the drug lowered key energy chain parts made by both the cell nucleus and the mitochondria themselves. The cells answered by reshaping their energy network and switching on a stress program. The findings help explain how this drug can derail early development.
Catalog record
| CREATOR | Zhihua Dong, Xueke Hou, Xueying Wang, Zihui Shen, Huiqing Pang, Lingli Chen, Zhihong Yin, Fei Ren, Weiguo Li, Yaming Ge, Hongmei Ning, Dongfang Hu, Youssef Sari |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |