Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile
Carolina Miranda-Vera, Ángela Patricia Hernández, Pilar García-García, David Díez, Pablo Anselmo García, María Ángeles Castro · 2023
Read Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile by Carolina Miranda-Vera, Ángela Patricia Hernández, Pilar García-García, David Díez, Pablo Anselmo García, María Ángeles Castro (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747284.txt.
Description
Carolina Miranda-Vera and co-authors review efforts to upgrade a plant compound into a better cancer fighter by fusing it with other molecules. Podophyllotoxin, drawn from mayapple roots, kills tumor cells but hits patients with harsh side effects. Its relatives already serve in the clinic, proof the scaffold has value. Chemists have therefore spent years reshaping it, and this review covers the changes published from 2017 to mid-2023.
Most edits target one ring of the molecule, with others touching its lactone and its three-crowned phenyl ring. The focus falls on hybrids: the compound stitched to other natural products, drug fragments, or ring systems, directly or through spacer links. Many hybrids show stronger or more selective tumor killing than the parent. The authors organize the catalog by junction style, hoping to steer the next round of designs toward safer, sharper anticancer agents.
Catalog record
| CREATOR | Carolina Miranda-Vera, Ángela Patricia Hernández, Pilar García-García, David Díez, Pablo Anselmo García, María Ángeles Castro |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |