Stability Studies of Antipseudomonal Beta Lactam Agents for Outpatient Therapy
Beatriz Fernández-Rubio, Laura Herrera-Hidalgo, Arístides de Alarcón, Rafael Luque-Márquez, Luis E. López-Cortés, Sònia Luque, José María Gutiérrez-Urbón, Aurora Fernández-Polo, Alicia Gutiérrez-Valencia, María V. Gil-Navarro · 2023
Read Stability Studies of Antipseudomonal Beta Lactam Agents for Outpatient Therapy by Beatriz Fernández-Rubio, Laura Herrera-Hidalgo, Arístides de Alarcón, Rafael Luque-Márquez, Luis E. López-Cortés, Sònia Luque, José María Gutiérrez-Urbón, Aurora Fernández-Polo, Alicia Gutiérrez-Valencia, María V. Gil-Navarro (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747133.txt.
Description
Patients with hard-to-treat infections can receive intravenous antibiotics at home, but only if the drug survives hours inside a pump worn at body warmth. Ten pharmacists and clinicians in Spain test nine antibiotics used against Pseudomonas and other resistant bacteria in 2023. Each drug is diluted in saline and stored at four temperatures for 72 hours. They try both plain infusion bags and elastomeric pumps. A drug counts as stable when its strength stays above 90 percent and its look and acidity hold.
All nine lasted three days in the fridge and at least 30 hours at room temperature. Heat sorted them: two meropenem products failed first, while five still held at 37 degrees after a day. Device type made no difference.
Catalog record
| CREATOR | Beatriz Fernández-Rubio, Laura Herrera-Hidalgo, Arístides de Alarcón, Rafael Luque-Márquez, Luis E. López-Cortés, Sònia Luque, José María Gutiérrez-Urbón, Aurora Fernández-Polo, Alicia Gutiérrez-Valencia, María V. Gil-Navarro |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |