New Insights for Polyphenolic Compounds as Naturally Inspired Proteasome Inhibitors
Emanuela Marchese, Maria Eugenia Gallo Cantafio, Francesca Alessandra Ambrosio, Roberta Torcasio, Ilenia Valentino, Francesco Trapasso, Giuseppe Viglietto, Stefano Alcaro, Giosuè Costa, Nicola Amodio · 2023
Read New Insights for Polyphenolic Compounds as Naturally Inspired Proteasome Inhibitors by Emanuela Marchese, Maria Eugenia Gallo Cantafio, Francesca Alessandra Ambrosio, Roberta Torcasio, Ilenia Valentino, Francesco Trapasso, Giuseppe Viglietto, Stefano Alcaro, Giosuè Costa, Nicola Amodio (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10747119.txt.
Description
Emanuela Marchese and nine co-authors test whether plant compounds can block the cell's protein shredder, in a 2023 study. That shredder, the proteasome, is a proven drug target in a blood cancer called multiple myeloma. Plant polyphenols guard health in many settings, yet this route was unexplored. The team screened eighty-six such compounds from a drug database on a computer.
Two compounds stood out for tight binding at the shredder's main cut site. Lab tests then showed both could slow that cut action. They also fought tumor cells in myeloma lines, even lines that resist known shredder drugs. The authors present the pair as leads for nature-inspired cancer drugs.
Catalog record
| CREATOR | Emanuela Marchese, Maria Eugenia Gallo Cantafio, Francesca Alessandra Ambrosio, Roberta Torcasio, Ilenia Valentino, Francesco Trapasso, Giuseppe Viglietto, Stefano Alcaro, Giosuè Costa, Nicola Amodio |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |