Retinal Ganglion Cell Fate Induction by Ngn-Family Transcription Factors
Ke Zhang, Wenwen Cai, Yanling Xin, Qinghai He, Canbin Chen, Mingbing Zeng, Shuyi Chen · 2023
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Description
Ke Zhang and co-authors report a 2023 study on regrowing the eye cells lost in glaucoma. Retinal ganglion cells carry signals from the retina to the brain, and their loss is what takes vision in this disease. The team tests whether a family of transcription factors, named Ngn1, Ngn2, and Ngn3, can push other cells into that fate.
In dish tests, viruses delivered each factor into mouse fibroblasts, and each one alone remade them into ganglion-like neurons. The new cells matched real ones in gene activity, fired with normal nerve properties, and formed working synapses with retinal neurons. In living mouse pups, the same factors steered late retinal progenitor cells to produce ganglion cells. The authors say the approach merits more work toward glaucoma therapy.
Catalog record
| CREATOR | Ke Zhang, Wenwen Cai, Yanling Xin, Qinghai He, Canbin Chen, Mingbing Zeng, Shuyi Chen |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |