Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez · 2023
Read Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse by Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10746880.txt.
Description
Gilles Willemin and co-authors compare mice missing a gene everywhere with mice missing it only in the liver, in a 2023 study. The gene, Maf1, brakes the cell's protein-building machinery. Losing it raises fat production in flies, worms, and mice. Whole-body knockout mice, though, stay lean. They burn the extra fat in a wasteful cycle of RNA making and scrapping.
Liver-only knockout mice told a different story. On rich diets they grew heavier and fatter than normal mice. The contrast shows the liver effect was masked by other tissues. Energy balance depends on where the brake is missing. Metabolism researchers gain a cautionary tale about whole-body knockouts. Tissue-specific studies can reverse the headline conclusion.
Catalog record
| CREATOR | Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |