Engineering Biomimetic Nanoparticles through Extracellular Vesicle Coating in Cancer Tissue Models
Gema Quiñonero, Juan Gallo, Alex Carrasco, Josep Samitier, Aranzazu Villasante · 2023
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Description
Gema Quinonero and co-authors dress tiny iron specks in a cancer cell's own coat in 2023, to help them slip into tumors. Bare drug specks face blocks: stray proteins coat them, aim goes off, immune cells attack, and dense tissue resists entry. Coats borrowed from cell-made bubbles may dodge those blocks.
The team first built a lab model of a nerve-cell tumor that lives at least twelve days, long enough to harvest the bubbles. Their iron specks were small, pure, and strongly magnetic. Tumor cells then took the specks in, the head reports. Dressing specks in the tumor's own shed coats is a sneaky idea: the tumor may welcome what looks like itself. Tests in the lab model show the path is workable.
Catalog record
| CREATOR | Gema Quiñonero, Juan Gallo, Alex Carrasco, Josep Samitier, Aranzazu Villasante |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |