The Angiopoietin Signaling Pathway Is Involved in Inflammatory Processes in Hospitalized COVID-19 Patients
Rachelle P. Mendoza, Amir Momeni, Nayanendu Saha, Juwairiya Arshi, Elmer C. Gabutan, Nichole Alejandro, Alejandro Zuretti, Prem K. Premsrirut, Dimitar B. Nikolov · 2023
Read The Angiopoietin Signaling Pathway Is Involved in Inflammatory Processes in Hospitalized COVID-19 Patients by Rachelle P. Mendoza, Amir Momeni, Nayanendu Saha, Juwairiya Arshi, Elmer C. Gabutan, Nichole Alejandro, Alejandro Zuretti, Prem K. Premsrirut, Dimitar B. Nikolov (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10745910.txt.
Description
Rachelle Mendoza and co-authors study a vessel signaling path in hospitalized COVID-19 patients, in a 2023 paper. The virus harms the vessel system as well as the lungs. Two related proteins guard vessel walls: one steadies them, and the other rises during swelling and new vessel growth. A known immune signal can trigger the second protein's path.
The team measured both proteins, the immune signal, and virus antibodies in patient blood. Samples spanned mild to severe disease, with healthy controls for contrast. The second protein was high in patients at every severity level. The first protein fell. The pattern fits the vessel injury seen in serious COVID-19 and may mark patients at risk of worse disease.
Catalog record
| CREATOR | Rachelle P. Mendoza, Amir Momeni, Nayanendu Saha, Juwairiya Arshi, Elmer C. Gabutan, Nichole Alejandro, Alejandro Zuretti, Prem K. Premsrirut, Dimitar B. Nikolov |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |