The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ-Exposed THP-1 Cells
Alessandro Maugeri, Caterina Russo, Giuseppe Tancredi Patanè, Davide Barreca, Giuseppina Mandalari, Michele Navarra · 2023
Read The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ-Exposed THP-1 Cells by Alessandro Maugeri, Caterina Russo, Giuseppe Tancredi Patanè, Davide Barreca, Giuseppina Mandalari, Michele Navarra (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10745857.txt.
Description
Maugeri and five co-authors test a kitchen spice blend against Alzheimer's-style inflammation in cells, in this two thousand twenty-three study. The blend mixes cinnamon bark with two turmeric extracts, and curcumin from turmeric is its best-known active part.
The team used immune cells exposed to the amyloid fragment that builds up in Alzheimer's brains. The blend cut reactive oxygen sharply and lowered two inflammatory messengers, IL-1 beta and IL-6, in both release and gene activity. It did so by damping three MAPK signaling switches and the NF-kappaB pathway, with one key phosphorylation falling by up to eighty-six percent. In test-tube antioxidant assays it outperformed a standard reference threefold. The authors propose the blend as a candidate worth further study for managing the disease.
Catalog record
| CREATOR | Alessandro Maugeri, Caterina Russo, Giuseppe Tancredi Patanè, Davide Barreca, Giuseppina Mandalari, Michele Navarra |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |