Adenoviral Vector Codifying for TNF as a Co-Adjuvant Therapy against Multi-Drug-Resistant Tuberculosis
Sujhey Hernández-Bazán, Dulce Mata-Espinosa, Octavio Ramos-Espinosa, Vasti Lozano-Ordaz, Jorge Barrios-Payán, Fernando López-Casillas, Rogelio Hernández-Pando, Eva Torres-Sangiao, Nelson C Soares, Monica Cartelle Gestal · 2023
Read Adenoviral Vector Codifying for TNF as a Co-Adjuvant Therapy against Multi-Drug-Resistant Tuberculosis by Sujhey Hernández-Bazán, Dulce Mata-Espinosa, Octavio Ramos-Espinosa, Vasti Lozano-Ordaz, Jorge Barrios-Payán, Fernando López-Casillas, Rogelio Hernández-Pando, Eva Torres-Sangiao, Nelson C Soares, Monica Cartelle Gestal (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10745769.txt.
Description
Sujhey Hernandez-Bazan and colleagues tested gene therapy against resistant tuberculosis in two thousand twenty-three. Drug-resistant TB needs longer, harsher treatment. Many patients abandon therapy midway. A virus carrier delivered a protective immune signal gene. Mice carried a resistant pulmonary infection strain. Treatment came during the chronic active stage.
One dose produced complete survival in treated mice. Lung bacterial loads fell sharply as well. Tissue damage and pneumonia shrank visibly. Immune cells in damaged areas rose in number. Protective granulomas grew larger and worked better. Control virus without the gene did nothing similar. Gene therapy could someday support failing drug regimens.
Catalog record
| CREATOR | Sujhey Hernández-Bazán, Dulce Mata-Espinosa, Octavio Ramos-Espinosa, Vasti Lozano-Ordaz, Jorge Barrios-Payán, Fernando López-Casillas, Rogelio Hernández-Pando, Eva Torres-Sangiao, Nelson C Soares, Monica Cartelle Gestal |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |