Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor
Jan Šegina, Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj, Antonio Massa · 2023
Read Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor by Jan Šegina, Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj, Antonio Massa (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10745536.txt.
Description
Jan Šegina and co-authors synthesize new carbene precursors from camphor, in a 2023 paper. The targets are six membered N-heterocyclic carbene starting materials, a class of catalysts prized in organic synthesis. Starting from a camphor derived acid, the team built both mirror orientations, endo and exo, with handedness controlled across five steps.
The new precursors were then tried in an asymmetric benzoin reaction, a classic test of carbene catalysis. Every compound was fully characterized, and absolute configurations were pinned down by X-ray diffraction and nuclear Overhauser measurements. The authors present the camphor scaffold as a cheap, natural source of chiral carbene precursors, ready for further catalyst tuning.
Catalog record
| CREATOR | Jan Šegina, Luka Ciber, Helena Brodnik, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj, Antonio Massa |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |