Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis
Joseph Boachie, Victor Zammit, Ponnusamy Saravanan, Antonysunil Adaikalakoteswari, Naoki Tanaka · 2023
Read Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis by Joseph Boachie, Victor Zammit, Ponnusamy Saravanan, Antonysunil Adaikalakoteswari, Naoki Tanaka (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10745523.txt.
Description
Joseph Boachie and co-authors show why metformin stops trimming liver fat when vitamin B12 runs low, and how adiponectin restores it. Long metformin use drains B12, and low B12 itself tracks fatty, disordered blood lipids. The team grows human liver cells in media with graded B12 levels to isolate the effect.
Their 2023 study finds low B12 piling triglycerides into the cells, switching fat-building genes on, and dimming fat burning and mitochondrial work. The energy sensor AMPK and its upstream hormone signal both sag. Metformin alone cannot fix the fat load in the low B12 state. Adding adiponectin reawakens the AMPK axis and clears the block, pointing to a paired fix for a common drug side effect.
Catalog record
| CREATOR | Joseph Boachie, Victor Zammit, Ponnusamy Saravanan, Antonysunil Adaikalakoteswari, Naoki Tanaka |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |