Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target
Vincent Hervin, Vincent Roy, Luigi A Agrofoglio, Chiara Brullo · 2023
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Description
Bacteria that resist many drugs at once have pushed the search for fresh antibiotics toward targets inside the bacterial wall-building pathway. Vincent Hervin and co-authors review one such target family in this 2023 paper: the Mur ligases, enzymes that assemble the wall material step by step. Four of them, MurC through MurF, do similar joining work. Because these enzymes share common active sites and structural features, the review presents them as a promising route to drugs that block several of them at once.
Catalog record
| CREATOR | Vincent Hervin, Vincent Roy, Luigi A Agrofoglio, Chiara Brullo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |