Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels
Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Evandro Piva, Carlos Enrique Cuevas Suárez · 2023
Read Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels by Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Evandro Piva, Carlos Enrique Cuevas Suárez (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744811.txt.
Description
Koichiro Hayashi and co-authors show that the shape of the empty space inside a bone scaffold steers how new bone and vessels grow. Surgeons use printed scaffolds to rebuild bone, and the inner channels decide how cells wander in. Their 2023 paper prints carbonate apatite scaffolds whose channels allow cell movement in one, two, or three dimensions, with the same gap size throughout.
The scaffolds sat in rabbit thigh bones for four weeks. In the one-dimensional channels, the new blood vessels grew two and a half to four times larger and far better aligned than in the freer spaces. Bone formation there was also about forty percent higher. The authors reason that single-file movement stops vessels from branching wastefully, while open spaces invite random wandering. The design lesson is simple and strong: narrow, directed channels grow the big, straight vessels that feeding new bone requires.
Catalog record
| CREATOR | Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa, Evandro Piva, Carlos Enrique Cuevas Suárez |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |