Amentoflavone Mitigates Cyclophosphamide-Induced Pulmonary Toxicity: Involvement of -SIRT-1/Nrf2/Keap1 Axis, JAK-2/STAT-3 Signaling, and Apoptosis
Mohamed F. Balaha, Ahmed A. Alamer, Rana M. Aldossari, Alhussain H. Aodah, Azza I. Helal, Ahmed M. Kabel · 2023
Read Amentoflavone Mitigates Cyclophosphamide-Induced Pulmonary Toxicity: Involvement of -SIRT-1/Nrf2/Keap1 Axis, JAK-2/STAT-3 Signaling, and Apoptosis by Mohamed F. Balaha, Ahmed A. Alamer, Rana M. Aldossari, Alhussain H. Aodah, Azza I. Helal, Ahmed M. Kabel (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744450.txt.
Description
Mohamed Balaha and co-authors test a plant compound against lung harm from a cancer drug in a 2023 rat study. The drug, cyclophosphamide, treats cancer and immune illness but can injure the lungs. The compound, amentoflavone, is known to fight cell stress and swelling.
Rats got the compound at two dose levels next to the harmful drug. The team checked lung wash fluid, stress markers, and key gene switches in lung tissue. They also viewed lung tissue under strong lenses. The design weighs guard paths in cells and signals tied to swelling and cell death. Results guide later work on guarding lungs during drug care.
Catalog record
| CREATOR | Mohamed F. Balaha, Ahmed A. Alamer, Rana M. Aldossari, Alhussain H. Aodah, Azza I. Helal, Ahmed M. Kabel |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |