New Perspective for Using Antimicrobial and Cell-Penetrating Peptides to Increase Efficacy of Antineoplastic 5-FU in Cancer Cells
Nuno Vale, Eduarda Ribeiro, Inês Cruz, Valentina Stulberg, Beate Koksch, Bárbara Costa, Dana Maria Copolovici, Robert Vasile Gradinaru · 2023
Read New Perspective for Using Antimicrobial and Cell-Penetrating Peptides to Increase Efficacy of Antineoplastic 5-FU in Cancer Cells by Nuno Vale, Eduarda Ribeiro, Inês Cruz, Valentina Stulberg, Beate Koksch, Bárbara Costa, Dana Maria Copolovici, Robert Vasile Gradinaru (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744333.txt.
Description
Nuno Vale and a team of co-authors explore using small peptides to carry a classic cancer drug into tumor cells. Their study appeared in twenty twenty-three. The drug, 5-FU, suffers from poor targeting and harsh side effects at the doses needed.
Two peptide families are candidates: germ-killing peptides and cell-penetrating peptides, both drawn to cell surfaces. The team screened their drug-like traits with computer tools, checking absorption, spread, breakdown, and toxicity. The peptides showed favorable profiles and hints of blocking a key drug-processing enzyme. In dishes, lung and bladder cancer cells were treated with the drug and peptides, and survival was measured. The goal is sharper delivery with less collateral harm.
Catalog record
| CREATOR | Nuno Vale, Eduarda Ribeiro, Inês Cruz, Valentina Stulberg, Beate Koksch, Bárbara Costa, Dana Maria Copolovici, Robert Vasile Gradinaru |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |