Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells
Takeshi Matsui, Lorenzo Alibardi, Simon J Conway · 2023
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Description
Takeshi Matsui, Lorenzo Alibardi, and Simon Conway review corneoptosis, the specialized cell death that builds the skin's outer barrier. Terrestrial life depends on the epidermis sealing the body against pathogens, toxins, and trauma. Its top layer, the stratum corneum, is literally made of dead cells that died on schedule.
The review follows epidermal development from the embryonic surface layer through the spinous and granular layers. In the granular layer, keratinocytes flatten and die through corneoptosis, stacking into the protective sheet. Matsui and colleagues dissect the mechanisms driving that transformation and the wider formation of the epidermis. Understanding the program matters for diseases where the barrier fails.
Catalog record
| CREATOR | Takeshi Matsui, Lorenzo Alibardi, Simon J Conway |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |