Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds
Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro, Giuseppina Laganà, Taeg Kyu Kwon · 2023
Read Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds by Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro, Giuseppina Laganà, Taeg Kyu Kwon (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744228.txt.
Description
Ferroptosis is a way cells die that depends on iron build-up, harmful oxygen byproducts, and damage to cell fats. Patanè and eight co-authors review what is known about this death pathway and its role in disease. Evidence links it to brain and heart diseases, and it can also kill tumor cells, which makes it a target for cancer treatment.
The review explains the main control points, including a transport system in the cell wall, a protective enzyme called GPx4, and drugs that bind iron. It then surveys compounds that trigger or block this cell death and weighs how each hits the pathway's key targets. The authors argue that steering ferroptosis could open new treatments across several diseases. They set out the open questions that drug developers must answer before such treatments reach patients.
Catalog record
| CREATOR | Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro, Giuseppina Laganà, Taeg Kyu Kwon |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |