Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats
María Sancho-Alonso, Yaiza M. Arenas, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Marta Llansola, Vicente Felipo · 2023
Read Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats by María Sancho-Alonso, Yaiza M. Arenas, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Marta Llansola, Vicente Felipo (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744193.txt.
Description
María Sancho-Alonso and co-authors trace the chain by which excess ammonia inflames the brain and dulls thinking, working in rats. Too much ammonia in the blood contributes to the confusion of liver disease, and inflamed brain tissue is part of the cause. The team focused on a receptor called S1PR2 in the hippocampus, the brain's memory hub, and blocked it with a drug delivered into the brain.
Blocking the receptor restored the rats' cognitive performance. The team mapped the full relay: extra ammonia raised a lipid signal, which raised an inflammatory messenger, which switched on a cascade through several proteins. The cascade woke the brain's immune cells, reshaped the receptors that handle the main excitatory signal, and locked inflammation in place. The authors propose the receptor as a drug target for the cognitive damage of liver disease.
Catalog record
| CREATOR | María Sancho-Alonso, Yaiza M. Arenas, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Marta Llansola, Vicente Felipo |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |