Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated Virus–Host Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Shen-Yuan Hsieh, George M Savva, Andrea Telatin, Sumeet K Tiwari, Mohammad A Tariq, Fiona Newberry, Katharine A Seton, Catherine Booth, Amolak S Bansal, Thomas Wileman, Evelien M Adriaenssens, Simon R Carding, Silvia Turroni · 2023
Read Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated Virus–Host Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by Shen-Yuan Hsieh, George M Savva, Andrea Telatin, Sumeet K Tiwari, Mohammad A Tariq, Fiona Newberry, Katharine A Seton, Catherine Booth, Amolak S Bansal, Thomas Wileman, Evelien M Adriaenssens, Simon R Carding, Silvia Turroni (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744171.txt.
Description
The gut holds trillions of viruses, mostly phages that infect bacteria, and their role in severe fatigue illness is unknown. Shen-Yuan Hsieh and eleven co-authors built a fuller picture of that virome in 2023, comparing healthy people with patients who have severe ME/CFS.
By combining virus particles fished from stool with whole-sample DNA reading, the team caught both free phages and viruses sleeping inside bacterial genomes. A core set of tailed phages appeared across people. Computer predictions then linked certain bacteria of the Anaerotruncus genus to viruses found only in patient samples. The authors offer the combined method as a frame for larger studies of virus-bacteria interplay in the disease.
Catalog record
| CREATOR | Shen-Yuan Hsieh, George M Savva, Andrea Telatin, Sumeet K Tiwari, Mohammad A Tariq, Fiona Newberry, Katharine A Seton, Catherine Booth, Amolak S Bansal, Thomas Wileman, Evelien M Adriaenssens, Simon R Carding, Silvia Turroni |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |