Identification of a Gene Encoding a New Fungal Steroid 7-Hydroxylase and Its Functional Characterization in Pichia pastoris Yeast
Vyacheslav Kollerov, Sergey Tarlachkov, Andrei Shutov, Alexey Kazantsev, Marina Donova · 2023
Read Identification of a Gene Encoding a New Fungal Steroid 7-Hydroxylase and Its Functional Characterization in Pichia pastoris Yeast by Vyacheslav Kollerov, Sergey Tarlachkov, Andrei Shutov, Alexey Kazantsev, Marina Donova (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10744122.txt.
Description
Vyacheslav Kollerov and four co-authors find a fungus gene for a prized chemical step in a 2023 study. The step adds an oxygen group to steroids at a rare spot, which helps make a bile drug and other medicines. The team had seen a mold do this step, and they hunted the gene that drives it.
Gene scans of the mold showed twelve genes that woke when fed a steroid food. The top gene was copied into a yeast host, where it did the step as hoped. The find gives drug makers a clean gene tool for a hard step in steroid craft.
Catalog record
| CREATOR | Vyacheslav Kollerov, Sergey Tarlachkov, Andrei Shutov, Alexey Kazantsev, Marina Donova |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |