The Inactivation of the Putative Two-Component System Sensor PA14_27940 Increases the Susceptibility to Several Antibiotics and Reduces the Motility of Pseudomonas aeruginosa
Roberta Genova, Teresa Gil-Gil, Trinidad Cuesta, José Luis Martínez, Fernando Sanz-García · 2023
Read The Inactivation of the Putative Two-Component System Sensor PA14_27940 Increases the Susceptibility to Several Antibiotics and Reduces the Motility of Pseudomonas aeruginosa by Roberta Genova, Teresa Gil-Gil, Trinidad Cuesta, José Luis Martínez, Fernando Sanz-García (2023) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-10743758.txt.
Description
Pseudomonas aeruginosa is a bacterium that resists many antibiotics, partly by pumping them out of the cell. Roberta Genova and co-authors studied a sensor gene in 2023 whose loss makes the bacterium more sensitive to several drugs. Earlier hints came from a mutant with a disruptive insertion, so the team made a clean deletion of the gene to rule out side effects on neighbors.
The deletion strain grew more sensitive to five antibiotics and moved less well, a trait tied to virulence. The pump system was still switched on by drugs, but more weakly, through a fault in its activator. Two other genes tied to cell wall recycling also fell. The authors name the sensor a good target for helper drugs.
Catalog record
| CREATOR | Roberta Genova, Teresa Gil-Gil, Trinidad Cuesta, José Luis Martínez, Fernando Sanz-García |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |