Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence
Alexander Kalinin, Ekaterina Zubkova, Mikhail Menshikov · 2023
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Description
Alexander Kalinin, Ekaterina Zubkova, and Mikhail Menshikov review a stress pathway that may drive cell aging. Their review, from twenty twenty-three, covers the integrated stress response. This ancient network reacts to cell stress by pausing most protein making. A few key proteins still get made, and they steer the cell's next moves.
Senescent cells stop dividing for good and pile up with age. They lack clean markers, which blocks drugs that would clear them. The authors argue the stress pathway sits near the center of that state. It also runs cleanup programs and guards the cell's power units. Its partner proteins and known modulators are mapped in detail.
Catalog record
| CREATOR | Alexander Kalinin, Ekaterina Zubkova, Mikhail Menshikov |
|---|---|
| YEAR | 2023 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |